Molecular Imaging Webinar Series
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"Optical Imaging of Anionic Membranes for Detecting and Monitoring Disease States In-Vivo"
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Abstract:
There is a major ongoing research effort to identify oligonucleotide and protein biomarkers of disease. While the use of phospholipid biomarkers are less common, there is increasing evidence that the membrane surfaces of certain cells and particles of biomedical significance (such as apoptotic cells, tumor vasculature, bacteria, and viruses), expose unusually high levels of negatively charged phospholipids.
Proteins and antibodies that can selectively target these anionic membrane surfaces and distinguish them from the near-neutral membrane surfaces of normal human cells have promising potential as imaging probes. It is often challenging to optimize the formulation and pharmaceutical properties of proteins, thus the need to develop small molecules that mimic these proteins and exhibit the same or enhanced targeting capabilities.
We will discuss the development of a series of fluorescent probes, each composed of synthetic zinc (II)-dipicolylamine affinity ligand conjugated to a near-infrared dye. These small molecule probes can target anionic membranes, permitting detection of bacterial infection, tumors, and tissue damage in living animals. Carestream Molecular Imaging’s In Vivo Multispectral Imaging System FX was utilized to evaluate the utility of these probes for binding anionic membranes in live animals. Longitudinal studies could be readily performed, as animals did not need to be sacrificed between experiments.
Speaker: Bryan A. Smith - graduate student in the laboratory of Bradley D. Smith, University of Notre Dame.
Seth Gammon – In Vivo Product Manager, Carestream Molecular Imaging |
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